We study the human immune system with a focus on T and B cell biology in the context of solid and hematopoietic malignancies. We are especially interested in the cues that drive clonal lymphocyte expansion and how malignancies can evade cellular immune responses. Our single cell technologies for T cell receptor and immunoglobulin sequencing in combination with high-dimensional phenotyping and functional profiling give insights into specificities and functional states of thousands of single cells in a high-throughput fashion.
Our goal is to identify and understand cancer-directed immune responses in order to
develop supportive strategies to immunologically eradicate cancer.
use these as highly sensitive and specific tumor markers.
design targeted (cellular) therapeutics.
Another focus is the identification and recombinant expression of virus-specific T cell receptors for adoptive transfer in the setting of allogeneic stem cell transplantation and post-transplant lymphoproliferative disorders.
Clonal T/B cell development, expansion, differentiation, and functions in hematopoietic malignancies
Susceptibility of molecularly defined T cell clones to immune checkpoint inhibition
Identification of clonal expansion of tumor-infiltrating and circulating T cells as molecular biomarkers in rectal cancer
T cell control of viral infections (EBV/CMV) in the setting of allogeneic stem cell transplantation