AG Priv.-Doz. Dr. med. Frederik Damm

The research group of Frederik Damm investigates genetic aberrations of hematologic malignancies. 

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Focus of research

The research group of Frederik Damm focuses on genetic events defining early steps during leukemo-/ lymphomagenesis using several molecular biology techniques. Combinations of various sequencing technologies using bulk and single-cell approaches help to develop novel models of precision oncology.  A broad national and international collaborating network supports investigations of rare tumor entities and/or molecularly defined subgroups.

Selected publications

  • Frick M, Chan W, Arends CM, ..., Damm F. Role of Donor Clonal Hematopoiesis in Allogeneic Hematopoietic Stem-Cell Transplantation. Journal of Clinical Oncology (Published online November 07, 2018). doi: 10.1200/JCO.2018.79.2184 PubMed
  • Arends CM, Galan-Sousa J, Hoyer K, …, Damm F. Hematopoietic lineage distribution and evolutionary dynamics of clonal hematopoiesis. Leukemia (2018). doi:10.1038/s41375-018-0047-7 PubMed
  • Young E, Noerenberg D, Mansouri L, ..., Damm F. EGR2 mutations define a new clinically aggressive subgroup of chronic lymphocytic leukemia. Leukemia 31, 1547–1554 (2017). doi:10.1038/leu.2016.359 PubMed
  • Mansouri L, Noerenberg D, Young E, ..., Damm F. Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphoma. Blood 128, 2666–2670 (2016). doi:10.1182/blood-2016-03-704528 PubMed
  • Damm F, Mylonas E, Cosson A, et al. Acquired Initiating Mutations in Early Hematopoietic Cells of CLL Patients. Cancer Discovery 4, 1088–1101 (2014). doi:10.1158/2159-8290.CD-14-0104 PubMed
  • Damm F, Chesnais V, Nagata Y, et al. BCOR and BCORL1 mutations in myelodysplastic syndromes and related disorders. Blood 122, 3169–3177 (2013). doi:10.1182/blood-2012-11-469619 PubMed
  • Damm F, Kosmider O, Gelsi-Boyer V, et al. Mutations affecting mRNA splicing define distinct clinical phenotypes and correlate with patient outcome in myelodysplastic syndromes. Blood 119, 3211–3218 (2012). doi:10.1182/blood-2011-12-400994 PubMed
  • Damm F, Oberacker T, Thol F, et al. Prognostic Importance of Histone Methyltransferase MLL5 Expression in Acute Myeloid Leukemia. Journal of Clinical Oncology 29, 682–689 (2011). doi:10.1200/JCO.2010.31.1118 PubMed